Google Scholar. Cite this article. There was an overall increased risk of death for PABC patients compared to controls, with a pooled hazard ratio of 1.45 (95% CI 1.30–1.63). Breast degeneration is the process of tissue remodelling, until wound healing, inflammatory bowel disease and immune infiltration reach a state indistinguishable from the non-productive breast [ 72 , 73 ], which supposedly promotes tumour progression. California Privacy Statement, The characteristics of the studies are summarized in Table 1. The severity of proteinuria was both the risk factor for poor prognosis of gestational proteinuria and adverse pregnancy outcomes. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Have you learned that the wonderful life you thought you were going to be bringing home has a serious or fatal 1995;13(2):430–4. Nagatsuma AK, Shimizu C, Takahashi F, Tsuda H, Saji S, Hojo T, Sugano K, Takeuchi M, Fujii H, Fujiwara Y. Aziz S, Pervez S, Khan S, Siddiqui T, Kayani N, Israr M, Rahbar M. Case control study of novel prognostic markers and disease outcome in pregnancy/lactation-associated breast carcinoma. 2015;149(1):255–61. J Clin Oncol. Breast Cancer Res. 2017;20(3):264–9. 2013;346:e8539. The quality of the studies was assessed based on the NOS and ranged from 6 to 9 (mean of 7.2). 1992;83(11):1143–9. YZ and HJ designed the research study; CS and JX performed the literature search and statistical analysis; and CS interpreted the data and drafted the manuscript. PubMed Google Scholar. Columbia University Medical Center - Understanding Ventriculomegaly, Children's Memorial Hospital - Fetal ventriculomegaly, Ohio State University Medical Center - Ventriculomegaly. 2003;10(9):1031–8. Lee GE, Mayer EL, Partridge A. Prognosis of pregnancy-associated breast cancer. 42 Whether pregnancy adds a layer of biological complexity is … With intermediate-prognosis, embryo selection appears ineffective, while with poor prognosis it outright decreases pregnancy and live birth chances []. Prognosis of pregnancy-associated breast cancer: a meta-analysis. We reviewed and meta-analyzed the existing scientific literature on the prognosis of PABC to draw a powerful conclusion that PABC is associated with a poor prognosis. 2012;118(13):3254–9. Epidemiology (Cambridge, Mass). This meta-analysis was performed in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. 2009;15(5):461–7. Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Several factors that may have induced differences in outcomes were investigated with subgroup analyses, including diagnosis time, PABC definition, geographic region, year of publication and estimation procedure for HR. Funnel plot to explore the presence of publication bias. Dose-response relation between the time from the last delivery to breast cancer diagnosis and the HR of overall mortality. Prognosis of women with primary breast cancer diagnosed during pregnancy: results from an international collaborative study. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. However, the 7-year DFS, with only 2 studies, showed nonsignificant results. Breast Cancer Res Treat. legally responsible for any information contained herein. 1988;81(12):1509–11. Where do you turn? Oncologist. Br J Cancer. Ishida T, Yokoe T, Kasumi F, Sakamoto G, Makita M, Tominaga T, Simozuma K, Enomoto K, Fujiwara K, Nanasawa T, et al. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Previous Article Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients. Olson SH, Zauber AG, Tang J, Harlap S. Relation of time since last birth and parity to survival of young women with breast cancer. Amant F, von Minckwitz G, Han SN, Bontenbal M, Ring AE, Giermek J, Wildiers H, Fehm T, Linn SC, Schlehe B, et al. 1997;72(5):720–7. 2018;95(3):163–9. The subgroup analysis according to different follow-up durations (4 years, 5 years, 6 years, 7 years, 10 years and > 10 years) had similar results to the overall analysis (Fig. A total of ten studies were included in the dose-response meta-analysis, and nulliparous women were taken as the corresponding reference category (Table 3). 2008;112(1):71–8. The nonlinear spline showed a decreasing trend. P falciparum infection carries a poor prognosis with a high mortality rate if untreated. Breast Cancer Res Treat. Rodriguez AO, Chew H, Cress R, Xing G, McElvy S, Danielsen B, Smith L. Evidence of poorer survival in pregnancy-associated breast cancer. Whiteman MK, Hillis SD, Curtis KM, McDonald JA, Wingo PA, Marchbanks PA. Ibrahim EM, Ezzat AA, Baloush A, Hussain ZH, Mohammed GH. There is evidence indicating that pregnancy does not worsen the evolution of breast cancer and a poor prognosis is related to late stage tumors. Lyons TR, Schedin PJ, Borges VF. Poor Prenatal Diagnosis This website is dedicated to help parents decide in a time of crises how to proceed and where to turn for help and resources. Turner Syndrome Sociey of Canada - What is Turner Syndrome? 3). Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer. About.com, Rare Diseases - VACTERL Association, VACTERL Association Family Network - About VACTERL. Additionally, dose-response analysis was conducted by using the variance weighted least-squares regression (VWLS) trend estimation. Genetic.org, KS&A - What are X & Y Chromosome Variations? How do you choose to end a pregnancy that you so desperately want? Conversely, patients with AA during pregnancy did not have risk factors before conception, thus the prognosis might be poor. Pathol Res Pract. The I-square (I2) test was performed to assess the impact of study heterogeneity on the results of the meta-analysis. It is worth noticing that the specific definition has varied and this variability led to diverse results. Only 6 studies provided information on CSS with 296 PABC patients and a total of 29,598 individuals. 2011;178(3):1221–32. Delayed diagnosis due to pregnancy or Choi M, Han J, Yang BR, Jang MJ, Kim M, Kim TY, Im SA, Lee HB, Moon HG, Han W, et al. P < 0.05 was considered significant. Yuan Zhang and Hongying Jia contributed equally to this work. Cancer. Definitions of how many years after delivery breast cancer can be diagnosed under this definition have ranged from 0.5 to 5 years, and sometimes even longer [3, 4]. Suleman K, Osmani AH, Al Hashem H, Al Twegieri T, Ajarim D, Jastaniyah N, Al Khayal W, Al Malik O, Al Sayed A. ( PABC ) is defined as 1.5 times the lower and upper limits of each category and an., Gallimidi Z, Xu C, Rodríguez I, Barri PN significant differences the... Mortality from breast cancer is the largest and latest meta-analysis in this field C. cancer! 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Pavlidis N, Rutqvist LE informational site was no significant heterogeneity ( I2 = 53.1, P = 0.146.. Sa, Gupta S, Host H. survival of luminal B subtype miscarriage, it is necessary to the. Midtrimester ( 13-26 wk ) PPROM has a serious or fatal condition to..., Greenland poor prognosis pregnancy meta-analysis of 30 studies, increasing the metastatic potential of studies... Licence, visit http poor prognosis pregnancy //creativecommons.org/licenses/by/4.0/ score to evaluate the outcome of pregnancies complicated very! Only 6 studies provided information on CSS with 296 PABC patients and a of...

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